Product Data Sheet
DNMT-IN-6
Catalog No. A57710
DNMT-IN-6 is a potent DNA methyltransferase inhibitor targeting DNMT1, DNMT3A, and DNMT3B. It promotes demethylation and restores expression of the TMS1 tumor suppressor gene, leading to apoptosis and G2/M phase cell cycle arrest. Additionally, DNMT-IN-6 disrupts mitochondrial integrity and activates the intrinsic caspase cascade (caspases 3, 7, and 9). This compound demonstrates potential in inhibiting tumor growth and enhancing survival in xenograft models, making it a valuable tool for cancer research, particularly in the study of diffuse large B-cell lymphoma.
Chemical Information
| Catalog Num | A57710 |
|---|---|
| M. Wt | 447.40 |
| Formula | C19H18AsNO3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3038316-36-5 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(C=C1)[As]2SCCCS2)/C=C/C3=CC4=C(OCO4)C=C3 |
Biological Activity
| Description | DNMT-IN-6 is a potent DNA methyltransferase inhibitor targeting DNMT1, DNMT3A, and DNMT3B. It promotes demethylation and restores expression of the TMS1 tumor suppressor gene, leading to apoptosis and G2/M phase cell cycle arrest. Additionally, DNMT-IN-6 disrupts mitochondrial integrity and activates the intrinsic caspase cascade (caspases 3, 7, and 9). This compound demonstrates potential in inhibiting tumor growth and enhancing survival in xenograft models, making it a valuable tool for cancer research, particularly in the study of diffuse large B-cell lymphoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
