Product Data Sheet
DNMT1-IN-3
Catalog No. A57711
DNMT1-IN-3 is a potent inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 of 0.777 μM and a KD of 0.183 μM. This compound selectively binds to the S-adenosyl-l-methionine (SAM) site on DNMT1, effectively disrupting its methylation activity. DNMT1-IN-3 demonstrates significant biological activity by inhibiting cell proliferation in K562 cells, primarily through the induction of apoptosis and cell cycle arrest in the G0/G1 phase. Its properties make it a valuable tool for research in hematologic tumors and epigenetic regulation.
Chemical Information
| Catalog Num | A57711 |
|---|---|
| M. Wt | 487.72 |
| Formula | C23H13Cl3N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3025012-68-1 |
| Synonyms | |
| SMILES | O=C(O)[C@@H](N(C(C1=C2C=CC=C1)=O)C2=O)CN3C4=C(C5=C3C=CC(Cl)=C5)C=C(Cl)C=C4Cl |
Biological Activity
| Description | DNMT1-IN-3 is a potent inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 of 0.777 μM and a KD of 0.183 μM. This compound selectively binds to the S-adenosyl-l-methionine (SAM) site on DNMT1, effectively disrupting its methylation activity. DNMT1-IN-3 demonstrates significant biological activity by inhibiting cell proliferation in K562 cells, primarily through the induction of apoptosis and cell cycle arrest in the G0/G1 phase. Its properties make it a valuable tool for research in hematologic tumors and epigenetic regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
