Product Data Sheet
DOT1L705
Catalog No. A57776
DOT1L705 is a PROTAC degrader that selectively targets DOT1L, facilitating the recruitment of the VHL E3 ubiquitin ligase for proteasomal degradation of the protein. This leads to a significant reduction in H3K79 methylation levels, ultimately decreasing the viability of leukemia cells. DOT1L705 is particularly relevant for research focused on MLL-rearranged leukemia, making it a valuable tool for investigating the underlying mechanisms of disease progression.
Chemical Information
| Catalog Num | A57776 |
|---|---|
| M. Wt | 1337.88 |
| Formula | C61H72ClF3N12O13S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3050756-34-5 |
| Synonyms | |
| SMILES | ClC1=C(N=CC=C1)[C@H](C2=C3OC(F)(OC3=CC=C2)F)NC4=C(C=C(C=C4)S(C)(=O)=O)NC5=NC(N6CCNCC6)=NC(OCCOCCOCCOCCOC7=CC(C8=C(N=CS8)C)=CC=C7CNC([C@@H]9C[C@H](CN9C([C@@H](NC(C%10(CC%10)F)=O)C(C)(C)C)=O)O)=O)=N5 |
Biological Activity
| Description | DOT1L705 is a PROTAC degrader that selectively targets DOT1L, facilitating the recruitment of the VHL E3 ubiquitin ligase for proteasomal degradation of the protein. This leads to a significant reduction in H3K79 methylation levels, ultimately decreasing the viability of leukemia cells. DOT1L705 is particularly relevant for research focused on MLL-rearranged leukemia, making it a valuable tool for investigating the underlying mechanisms of disease progression. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
