Product Data Sheet
PSB 0777 ammonium
Catalog No. A57930
PSB 0777 ammonium is a selective agonist of the adenosine A2A receptor, demonstrating a Ki of 44.4 nM for the rat A2A receptor and 360 nM for the human A2A receptor. It shows significantly reduced affinity for the A1 receptor, with Ki values exceeding 10,000 nM for rats and 541 nM for humans. While PSB 0777 ammonium exhibits limited brain penetration and is not orally absorbable, it holds potential for research applications in inflammatory bowel disease (IBS).
Chemical Information
| Catalog Num | A57930 |
|---|---|
| M. Wt | 500.55 |
| Formula | C18H24N6O7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2122196-16-9 |
| Synonyms | |
| SMILES | OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=C(SCCC4=CC=C(S(=O)([O-])=O)C=C4)N=C32)N)O1)O)O.[NH4+] |
Biological Activity
| Description | PSB 0777 ammonium is a selective agonist of the adenosine A2A receptor, demonstrating a Ki of 44.4 nM for the rat A2A receptor and 360 nM for the human A2A receptor. It shows significantly reduced affinity for the A1 receptor, with Ki values exceeding 10,000 nM for rats and 541 nM for humans. While PSB 0777 ammonium exhibits limited brain penetration and is not orally absorbable, it holds potential for research applications in inflammatory bowel disease (IBS). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
