Product Data Sheet
LJ-4517
Catalog No. A57971
LJ-4517 is a highly selective antagonist of the adenosine A2A receptor (A2AAR) with a binding affinity (Ki) of 18.3 nM. This compound effectively displaces the binding of [3H]ZM241385 at wild-type A2AAR, demonstrating its potency in modulating adenosine signaling pathways. Additionally, LJ-4517 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) applications. This dual functionality makes it a valuable tool for diverse biochemical research.
Chemical Information
| Catalog Num | A57971 |
|---|---|
| M. Wt | 399.47 |
| Formula | C19H21N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2988849-20-1 |
| Synonyms | |
| SMILES | O[C@H]1[C@H](N2C(C3=CC=CS3)=NC4=C(N)N=C(C#CCCCC)N=C24)OC[C@H]1O |
Biological Activity
| Description | LJ-4517 is a highly selective antagonist of the adenosine A2A receptor (A2AAR) with a binding affinity (Ki) of 18.3 nM. This compound effectively displaces the binding of [3H]ZM241385 at wild-type A2AAR, demonstrating its potency in modulating adenosine signaling pathways. Additionally, LJ-4517 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) applications. This dual functionality makes it a valuable tool for diverse biochemical research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
