Product Data Sheet
LJ-2698
Catalog No. A57981
LJ-2698 is an orally active antagonist of the adenosine A3 receptor. This compound demonstrates significant anti-inflammatory effects by increasing levels of anti-inflammatory cytokines and promoting the proliferation of M2 macrophages in lung tissues, leading to improved pulmonary function and reduced alveolar cavity enlargement. Additionally, LJ-2698 has shown potential in preventing renal injury associated with diabetic nephropathy by inhibiting lipid accumulation and enhancing PGC1α expression in renal tissues. This reagent is suitable for research applications related to emphysema and diabetic nephropathy.
Chemical Information
| Catalog Num | A57981 |
|---|---|
| M. Wt | 412.29 |
| Formula | C16H15Cl2N5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 945457-84-1 |
| Synonyms | |
| SMILES | N(CC1=CC(Cl)=CC=C1)C2=C3C(N(C=N3)[C@H]4[C@H](O)[C@H](O)CS4)=NC(Cl)=N2 |
Biological Activity
| Description | LJ-2698 is an orally active antagonist of the adenosine A3 receptor. This compound demonstrates significant anti-inflammatory effects by increasing levels of anti-inflammatory cytokines and promoting the proliferation of M2 macrophages in lung tissues, leading to improved pulmonary function and reduced alveolar cavity enlargement. Additionally, LJ-2698 has shown potential in preventing renal injury associated with diabetic nephropathy by inhibiting lipid accumulation and enhancing PGC1α expression in renal tissues. This reagent is suitable for research applications related to emphysema and diabetic nephropathy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
