Product Data Sheet
AMP-579
Catalog No. A57990
AMP-579 is an adenosine receptor agonist targeting the adenosine A1 and A2A receptors, exhibiting Ki values of 1.7 nM and 4.5 nM for A1 receptors in rat brain and adipocytes, and a Ki value of 56 nM for A2A receptors in rat brain. This compound effectively inhibits lipolysis and restores insulin-dependent glucose transport through A1 receptor activation, while it promotes vasodilation, especially in coronary arteries, via A2A receptor activation with an IC50 of 0.3 μM in porcine coronary arterial rings. AMP-579 holds potential in cardioprotection and the therapeutic management of acute myocardial infarction.
Chemical Information
| Catalog Num | A57990 |
|---|---|
| M. Wt | 478.01 |
| Formula | C22H28ClN5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 213453-89-5 |
| Synonyms | |
| SMILES | O[C@H]1[C@@H](C[C@@H]([C@H]1O)C(NCC)=O)N2C3=NC=NC(N[C@H](CC)CC4=C(C=CS4)Cl)=C3C=C2 |
Biological Activity
| Description | AMP-579 is an adenosine receptor agonist targeting the adenosine A1 and A2A receptors, exhibiting Ki values of 1.7 nM and 4.5 nM for A1 receptors in rat brain and adipocytes, and a Ki value of 56 nM for A2A receptors in rat brain. This compound effectively inhibits lipolysis and restores insulin-dependent glucose transport through A1 receptor activation, while it promotes vasodilation, especially in coronary arteries, via A2A receptor activation with an IC50 of 0.3 μM in porcine coronary arterial rings. AMP-579 holds potential in cardioprotection and the therapeutic management of acute myocardial infarction. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
