Product Data Sheet
A2AR modulator-1
Catalog No. A58002
A2AR modulator-1 is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR) with an IC50 value of 9 nM. This compound reduces the affinity of endogenous adenosine for A2aR and inhibits activation of the cAMP signaling pathway. A2AR modulator-1 effectively enhances pCREB phosphorylation in CD4+ T cells, counteracting immunosuppression in the tumor microenvironment. Its ability to suppress tumor growth and metastasis has been demonstrated in models of triple-negative breast cancer, highlighting its potential in cancer research.
Chemical Information
| Catalog Num | A58002 |
|---|---|
| M. Wt | 380.45 |
| Formula | C23H20N6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3007566-23-3 |
| Synonyms | |
| SMILES | N#CC1=C(C2=CC=CC(C3=CC=CN=C3)=C2)C(C#N)=C(N4CCCCC4)N=C1N |
Biological Activity
| Description | A2AR modulator-1 is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR) with an IC50 value of 9 nM. This compound reduces the affinity of endogenous adenosine for A2aR and inhibits activation of the cAMP signaling pathway. A2AR modulator-1 effectively enhances pCREB phosphorylation in CD4+ T cells, counteracting immunosuppression in the tumor microenvironment. Its ability to suppress tumor growth and metastasis has been demonstrated in models of triple-negative breast cancer, highlighting its potential in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
