Product Data Sheet
Glucagon receptor antagonist-7
Catalog No. A58103
Glucagon receptor antagonist-7 is a potent inhibitor of the human glucagon receptor (hGCGR), demonstrating an IC50 of 181 nM for blocking the binding of 125I-labeled glucagon. With a KDB of 81 nM, it inhibits glucagon-stimulated adenylyl cyclase activity in CHO cells. This compound effectively reduces glucagon-mediated glycogenolysis in human hepatocytes and has been shown to lower blood glucose levels, making it a valuable tool for research in glucose metabolism and diabetes therapeutic strategies.
Chemical Information
| Catalog Num | A58103 |
|---|---|
| M. Wt | 346.53 |
| Formula | C20H30N2OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 438618-32-7 |
| Synonyms | |
| SMILES | CCC(CC)C(NC1=C(C#N)C(CCC(C(C)(C)CC)C2)=C2S1)=O |
Biological Activity
| Description | Glucagon receptor antagonist-7 is a potent inhibitor of the human glucagon receptor (hGCGR), demonstrating an IC50 of 181 nM for blocking the binding of 125I-labeled glucagon. With a KDB of 81 nM, it inhibits glucagon-stimulated adenylyl cyclase activity in CHO cells. This compound effectively reduces glucagon-mediated glycogenolysis in human hepatocytes and has been shown to lower blood glucose levels, making it a valuable tool for research in glucose metabolism and diabetes therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
