Product Data Sheet
L748337
Catalog No. A58120
L748337 is a selective β3-adrenergic receptor antagonist with a high affinity for the β3 receptor (Ki = 4.0 nM) compared to β1 (Ki = 390 nM) and β2 receptors (Ki = 204 nM). This compound predominantly couples to Gi proteins, leading to the activation of MAPK signaling pathways, which subsequently enhances the phosphorylation of Erk1/2 with a pEC50 value of 11.6. L748337 is applicable in research focused on cancer, nonalcoholic fatty liver disease (NAFLD), and various cardiovascular disorders.
Chemical Information
| Catalog Num | A58120 |
|---|---|
| M. Wt | 497.61 |
| Formula | C26H31N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 244192-94-7 |
| Synonyms | |
| SMILES | CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C2)=C1)=O |
Biological Activity
| Description | L748337 is a selective β3-adrenergic receptor antagonist with a high affinity for the β3 receptor (Ki = 4.0 nM) compared to β1 (Ki = 390 nM) and β2 receptors (Ki = 204 nM). This compound predominantly couples to Gi proteins, leading to the activation of MAPK signaling pathways, which subsequently enhances the phosphorylation of Erk1/2 with a pEC50 value of 11.6. L748337 is applicable in research focused on cancer, nonalcoholic fatty liver disease (NAFLD), and various cardiovascular disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
