Product Data Sheet
Tilisolol hydrochloride
Catalog No. A58219
Tilisolol hydrochloride is a non-selective β-adrenergic antagonist that acts primarily on adrenergic receptors, demonstrating significant vasodilatory and hypotensive effects. This compound promotes relaxation of smooth muscle in canine coronary arteries through the opening of ATP-sensitive K+ channels and exhibits concentration-dependent relaxation in KCl-precontracted rat thoracic aorta. Additionally, tilisolol hydrochloride has been shown to reduce diastolic blood pressure in a dose-dependent manner, with a mild increase in heart rate observed in spinal cord-stimulated rats. It is widely used in cardiovascular research to study adrenergic signaling and blood pressure regulation.
Chemical Information
| Catalog Num | A58219 |
|---|---|
| M. Wt | 340.85 |
| Formula | C17H25ClN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 62774-96-3 |
| Synonyms | N-696 |
| SMILES | O=C1C2=C(C(OCC(CNC(C)(C)C)O)=CN1C)C=CC=C2.Cl |
Biological Activity
| Description | Tilisolol hydrochloride is a non-selective β-adrenergic antagonist that acts primarily on adrenergic receptors, demonstrating significant vasodilatory and hypotensive effects. This compound promotes relaxation of smooth muscle in canine coronary arteries through the opening of ATP-sensitive K+ channels and exhibits concentration-dependent relaxation in KCl-precontracted rat thoracic aorta. Additionally, tilisolol hydrochloride has been shown to reduce diastolic blood pressure in a dose-dependent manner, with a mild increase in heart rate observed in spinal cord-stimulated rats. It is widely used in cardiovascular research to study adrenergic signaling and blood pressure regulation. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
