Product Data Sheet
ARC 239 dihydrochloride
Catalog No. A58234
ARC 239 dihydrochloride is a selective antagonist of the α2B and α2C adrenoceptors, demonstrating pKd values of 5.95, 7.41, and 7.56 at the α2A, α2B, and α2C receptors, respectively. This compound effectively binds to CHO cell membranes expressing human recombinant α2A, α2B, and α2C adrenoceptor subtypes, showing pKi values of 5.6, 8.4, and 7.08. ARC 239 dihydrochloride is valuable for research applications in studying adrenergic signaling pathways and the physiological roles of α2 adrenergic receptors.
Chemical Information
| Catalog Num | A58234 |
|---|---|
| M. Wt | 480.43 |
| Formula | C24H31Cl2N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 55974-42-0 |
| Synonyms | |
| SMILES | O=C1C2=C(C(C)(C)C(N1CCN3CCN(CC3)C4=C(OC)C=CC=C4)=O)C=CC=C2.Cl.Cl |
Biological Activity
| Description | ARC 239 dihydrochloride is a selective antagonist of the α2B and α2C adrenoceptors, demonstrating pKd values of 5.95, 7.41, and 7.56 at the α2A, α2B, and α2C receptors, respectively. This compound effectively binds to CHO cell membranes expressing human recombinant α2A, α2B, and α2C adrenoceptor subtypes, showing pKi values of 5.6, 8.4, and 7.08. ARC 239 dihydrochloride is valuable for research applications in studying adrenergic signaling pathways and the physiological roles of α2 adrenergic receptors. |
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RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
