Product Data Sheet
Upidosin
Catalog No. A58274
Upidosin is an α-1 adrenergic receptor (α-1 AR) antagonist with moderate selectivity for the α-1A AR subtype. It demonstrates uroselectivity, exhibiting a Kb value of 2-3 nM in the urethra and prostate, compared to Kb values of 20-100 nM in the ear artery and aorta. Upidosin effectively inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptors. This compound is a valuable tool for research focused on urethral obstruction and related conditions.
Chemical Information
| Catalog Num | A58274 |
|---|---|
| M. Wt | 511.61 |
| Formula | C31H33N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 152735-23-4 |
| Synonyms | Rec 15/2739; Recordati 15/2739; SB 216469 |
| SMILES | COC(C=CC=C1)=C1N(CC2)CCN2CCCNC(C3=C4C(C(C(C)=C(C5=CC=CC=C5)O4)=O)=CC=C3)=O |
Biological Activity
| Description | Upidosin is an α-1 adrenergic receptor (α-1 AR) antagonist with moderate selectivity for the α-1A AR subtype. It demonstrates uroselectivity, exhibiting a Kb value of 2-3 nM in the urethra and prostate, compared to Kb values of 20-100 nM in the ear artery and aorta. Upidosin effectively inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptors. This compound is a valuable tool for research focused on urethral obstruction and related conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
