Product Data Sheet
Benzquinamide hydrochloride
Catalog No. A58277
Benzquinamide hydrochloride targets the α2 adrenergic receptors (α2-AR), binding with Ki values of 1,365, 691, and 545 nM for the α2A, α2B, and α2C subtypes, respectively. As an antiemetic, it exhibits significant efficacy in preventing nausea and vomiting. Additionally, benzquinamide inhibits P-glycoprotein-mediated drug efflux, thereby enhancing the cytotoxic effects of anticancer agents in multidrug-resistant cell lines, making it a valuable tool in cancer research and therapeutic development.
Chemical Information
| Catalog Num | A58277 |
|---|---|
| M. Wt | 440.96 |
| Formula | C22H33ClN2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113-69-9 |
| Synonyms | P2647 hydrochloride; BZQ hydrochloride; Benzoquinamide hydrochloride |
| SMILES | O=C(C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O)N(CC)CC.[H]Cl |
Biological Activity
| Description | Benzquinamide hydrochloride targets the α2 adrenergic receptors (α2-AR), binding with Ki values of 1,365, 691, and 545 nM for the α2A, α2B, and α2C subtypes, respectively. As an antiemetic, it exhibits significant efficacy in preventing nausea and vomiting. Additionally, benzquinamide inhibits P-glycoprotein-mediated drug efflux, thereby enhancing the cytotoxic effects of anticancer agents in multidrug-resistant cell lines, making it a valuable tool in cancer research and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
