Product Data Sheet
Prazobind-d8
Catalog No. A58332
Prazobind-d8 is a deuterium-labeled analog of Prazobind, functioning as an irreversible antagonist of the α1-adrenoceptor. With an IC50 value of 1 nM, Prazobind-d8 exhibits potent competitive binding to α1-adrenoceptor subtypes, specifically in the hippocampus and liver. This compound partially inhibits contractions in smooth, circular, and longitudinal muscle tissues, making it a valuable tool for investigating mechanisms related to blood pressure regulation and related cardiovascular research.
Chemical Information
| Catalog Num | A58332 |
|---|---|
| M. Wt | 429.54 |
| Formula | C23H19D8N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189701-23-2 |
| Synonyms | SZL 49-d8 |
| SMILES | NC1=NC(N2C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C2([2H])[2H])C(C3=CC4CCC3C=C4)=O)=NC5=C1C=C(OC)C(OC)=C5 |
Biological Activity
| Description | Prazobind-d8 is a deuterium-labeled analog of Prazobind, functioning as an irreversible antagonist of the α1-adrenoceptor. With an IC50 value of 1 nM, Prazobind-d8 exhibits potent competitive binding to α1-adrenoceptor subtypes, specifically in the hippocampus and liver. This compound partially inhibits contractions in smooth, circular, and longitudinal muscle tissues, making it a valuable tool for investigating mechanisms related to blood pressure regulation and related cardiovascular research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
