Product Data Sheet
RWJ52353 hydrochloride
Catalog No. A58367
RWJ52353 hydrochloride is a selective agonist for the α2D adrenergic receptor, exhibiting a binding affinity with a Ki value of 1.5 nM. This compound has demonstrated significant analgesic properties in animal models, including efficacy in abdominal pain tests and reduced agitation in rodents as assessed by the hot plate and tail flick tests. Additionally, RWJ52353 hydrochloride influences the activity of organic cation transporters, effectively inhibiting rOCT1 and rOCT2, while activating rOCT3, which impacts the transport of [3H]-1-methyl-4-phenylpyridinium in cellular systems.
Chemical Information
| Catalog Num | A58367 |
|---|---|
| M. Wt | 238.74 |
| Formula | C11H11ClN2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 245744-13-2 |
| Synonyms | |
| SMILES | C1(C2=CCCC3=C2C=CS3)=CN=CN1.Cl |
Biological Activity
| Description | RWJ52353 hydrochloride is a selective agonist for the α2D adrenergic receptor, exhibiting a binding affinity with a Ki value of 1.5 nM. This compound has demonstrated significant analgesic properties in animal models, including efficacy in abdominal pain tests and reduced agitation in rodents as assessed by the hot plate and tail flick tests. Additionally, RWJ52353 hydrochloride influences the activity of organic cation transporters, effectively inhibiting rOCT1 and rOCT2, while activating rOCT3, which impacts the transport of [3H]-1-methyl-4-phenylpyridinium in cellular systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
