Product Data Sheet
Harman-13C2,15N
Catalog No. A58386
Harman-13C2,15N is a stable isotope-labeled derivative of Harmane, a known benzodiazepine receptor antagonist (IC50 = 7 μM). This compound exhibits notable affinity for various biological targets, including mACh (IC50 = 24 μM), Opioid Receptor (IC50 = 2.8 μM), MAO-A/B (IC50 = 0.5 μM), and the α2-adrenergic receptor (IC50 = 5 μM). Harmane is recognized for its diverse pharmacological activities, such as reducing blood pressure via I1 imidazoline receptor inhibition (IC50 = 30 nM), as well as demonstrating antidepressant, anti-anxiety, anticonvulsant, and analgesic properties. Additionally, it has been shown to affect dopamine biosynthesis and enhance mutagenic effects in specific cellular assays.
Chemical Information
| Catalog Num | A58386 |
|---|---|
| M. Wt | 185.20 |
| Formula | C1013C2H10N15N |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189461-56-0 |
| Synonyms | |
| SMILES | CC1=[15N][13CH]=[13CH]C2=C1NC3=C2C=CC=C3 |
Biological Activity
| Description | Harman-13C2,15N is a stable isotope-labeled derivative of Harmane, a known benzodiazepine receptor antagonist (IC50 = 7 μM). This compound exhibits notable affinity for various biological targets, including mACh (IC50 = 24 μM), Opioid Receptor (IC50 = 2.8 μM), MAO-A/B (IC50 = 0.5 μM), and the α2-adrenergic receptor (IC50 = 5 μM). Harmane is recognized for its diverse pharmacological activities, such as reducing blood pressure via I1 imidazoline receptor inhibition (IC50 = 30 nM), as well as demonstrating antidepressant, anti-anxiety, anticonvulsant, and analgesic properties. Additionally, it has been shown to affect dopamine biosynthesis and enhance mutagenic effects in specific cellular assays. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
