Product Data Sheet
L-771688 hydrochloride
Catalog No. A58391
L-771688 hydrochloride is a highly potent and selective α1A-adrenoceptor antagonist, exhibiting a Kd of 43-90 pM. It demonstrates strong affinity for cloned human, rat, and canine α1A-adrenergic receptors, with a Ki of less than 1 nM and over 500-fold selectivity against the α1B and α1D isoforms. L-771688 effectively blocks norepinephrine-induced responses, making it useful for studying adrenergic signaling pathways. Its ability to inhibit contractions induced by phenylephrine or A-61603 in various animal models further underscores its applications in cardiovascular research.
Chemical Information
| Catalog Num | A58391 |
|---|---|
| M. Wt | 630.51 |
| Formula | C28H35Cl2F2N5O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 200051-19-0 |
| Synonyms | |
| SMILES | O=C(C([C@H](C1=CC=C(F)C(F)=C1)N2C(NCCCN3CCC(C4=NC=CC=C4)CC3)=O)=C(COC)NC2=O)OC.Cl.Cl |
Biological Activity
| Description | L-771688 hydrochloride is a highly potent and selective α1A-adrenoceptor antagonist, exhibiting a Kd of 43-90 pM. It demonstrates strong affinity for cloned human, rat, and canine α1A-adrenergic receptors, with a Ki of less than 1 nM and over 500-fold selectivity against the α1B and α1D isoforms. L-771688 effectively blocks norepinephrine-induced responses, making it useful for studying adrenergic signaling pathways. Its ability to inhibit contractions induced by phenylephrine or A-61603 in various animal models further underscores its applications in cardiovascular research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
