Product Data Sheet
DL-017
Catalog No. A58399
DL-017 is a Quinazoline derivative that exhibits potent inhibition of α1-adrenergic receptors, with an IC50 of approximately 0.90 nM, and Na+ channels, with an IC50 of 404 nM. Its robust antihypertensive activity makes DL-017 a valuable reagent for studying cardiovascular mechanisms and exploring therapeutic avenues for hypertension. This compound serves as a crucial tool in pharmacological research and drug development focused on adrenergic modulation and ion channel interactions.
Chemical Information
| Catalog Num | A58399 |
|---|---|
| M. Wt | 421.56 |
| Formula | C23H27N5OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 149847-79-0 |
| Synonyms | |
| SMILES | CSC1=NC2=C(C=CC=C2)C3=NCC(CN4CCN(C5=CC=CC=C5OC)CC4)N13 |
Biological Activity
| Description | DL-017 is a Quinazoline derivative that exhibits potent inhibition of α1-adrenergic receptors, with an IC50 of approximately 0.90 nM, and Na+ channels, with an IC50 of 404 nM. Its robust antihypertensive activity makes DL-017 a valuable reagent for studying cardiovascular mechanisms and exploring therapeutic avenues for hypertension. This compound serves as a crucial tool in pharmacological research and drug development focused on adrenergic modulation and ion channel interactions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
