Product Data Sheet
FMS586 free base
Catalog No. A58414
FMS586 free base is a selective antagonist of the neuropeptide Y Y5 receptor, exhibiting oral bioactivity. It effectively inhibits the hPP-induced increase in adrenocorticotropic hormone (ACTH) and cortisol levels, and reverses the upregulation of corticotropin-releasing hormone (CRF) and vasopressin (AVP) mRNA expression following central administration of hPP. This compound offers valuable insights into the role of Y5 receptors in activating the hypothalamic-pituitary-adrenal (HPA) axis, making it a significant tool for studying neuroendocrine regulation.
Chemical Information
| Catalog Num | A58414 |
|---|---|
| M. Wt | 390.52 |
| Formula | C24H30N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 302556-51-0 |
| Synonyms | |
| SMILES | O=C(N(CCC1=CC=NC=C1)C)NC2=CC3=C(N(C4=C3CCCC4)C(C)C)C=C2 |
Biological Activity
| Description | FMS586 free base is a selective antagonist of the neuropeptide Y Y5 receptor, exhibiting oral bioactivity. It effectively inhibits the hPP-induced increase in adrenocorticotropic hormone (ACTH) and cortisol levels, and reverses the upregulation of corticotropin-releasing hormone (CRF) and vasopressin (AVP) mRNA expression following central administration of hPP. This compound offers valuable insights into the role of Y5 receptors in activating the hypothalamic-pituitary-adrenal (HPA) axis, making it a significant tool for studying neuroendocrine regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
