Product Data Sheet
L-654284
Catalog No. A58433
L-654284 is a selective α2-adrenergic receptor antagonist that effectively competes with the binding of radiolabeled 3H-clonidine and 3H-rauwolscine, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. This compound demonstrates the ability to block the effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. Additionally, L-654284 shows notable selectivity towards α2 and α1 adrenergic receptors, with a Ki of 110 nM against 3H-prazosin binding. In vivo studies reveal that L-654284 enhances norepinephrine turnover in the rat cerebral cortex, highlighting its potential applications in research related to central nervous system pharmacology.
Chemical Information
| Catalog Num | A58433 |
|---|---|
| M. Wt | 364.46 |
| Formula | C18H24N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 98719-20-1 |
| Synonyms | |
| SMILES | OCCS(N([C@H]1C[C@@]2([H])C3=C(CCN2CC1)C4=CC=CC=C4O3)C)(=O)=O |
Biological Activity
| Description | L-654284 is a selective α2-adrenergic receptor antagonist that effectively competes with the binding of radiolabeled 3H-clonidine and 3H-rauwolscine, exhibiting Ki values of 0.8 nM and 1.1 nM, respectively. This compound demonstrates the ability to block the effects of clonidine in isolated rat vas deferens, with a pA2 value of 9.1. Additionally, L-654284 shows notable selectivity towards α2 and α1 adrenergic receptors, with a Ki of 110 nM against 3H-prazosin binding. In vivo studies reveal that L-654284 enhances norepinephrine turnover in the rat cerebral cortex, highlighting its potential applications in research related to central nervous system pharmacology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
