Product Data Sheet
BRL-41992
Catalog No. A58490
BRL-41992 is a selective antagonist of the α₂B-adrenergic receptor, demonstrating 94-fold greater selectivity for this subtype compared to the α₂A-receptor. It exhibits Kᵢ values of 1.1 nM in neonatal rat lung tissue, where the α₂B-receptor is expressed, and 103.3 nM in human platelet membranes, which express the α₂A-receptor. This compound is valuable for studying the functional differences between α₂ receptor subtypes in various biological contexts.
Chemical Information
| Catalog Num | A58490 |
|---|---|
| M. Wt | 264.36 |
| Formula | C18H20N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 124097-52-5 |
| Synonyms | |
| SMILES | CN(CN1[C@]2(C3=CC=CC=C3CC4=CC=CC=C41)[H])[C@@H]2C |
Biological Activity
| Description | BRL-41992 is a selective antagonist of the α₂B-adrenergic receptor, demonstrating 94-fold greater selectivity for this subtype compared to the α₂A-receptor. It exhibits Kᵢ values of 1.1 nM in neonatal rat lung tissue, where the α₂B-receptor is expressed, and 103.3 nM in human platelet membranes, which express the α₂A-receptor. This compound is valuable for studying the functional differences between α₂ receptor subtypes in various biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
