Product Data Sheet
CGP 12177
Catalog No. A58492
CGP 12177 is a selective β-Adrenergic receptor (β-AR) ligand that primarily acts as a β3-AR agonist (Ki = 88 nM) while displaying antagonist activity at β1 (Ki = 0.9 nM) and β2-AR (Ki = 4 nM). Additionally, it demonstrates partial agonist characteristics for α1-AR in rat pulmonary artery tissues. This compound is relevant for research investigating the regulation of metabolic pathways, particularly the expression of ucp and leptin genes in adipose tissues, and holds potential applications in cardiovascular and metabolic disease studies.
Chemical Information
| Catalog Num | A58492 |
|---|---|
| M. Wt | 279.33 |
| Formula | C14H21N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 81047-99-6 |
| Synonyms | (±)-CGP 12177 |
| SMILES | O=C1NC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1 |
Biological Activity
| Description | CGP 12177 is a selective β-Adrenergic receptor (β-AR) ligand that primarily acts as a β3-AR agonist (Ki = 88 nM) while displaying antagonist activity at β1 (Ki = 0.9 nM) and β2-AR (Ki = 4 nM). Additionally, it demonstrates partial agonist characteristics for α1-AR in rat pulmonary artery tissues. This compound is relevant for research investigating the regulation of metabolic pathways, particularly the expression of ucp and leptin genes in adipose tissues, and holds potential applications in cardiovascular and metabolic disease studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
