Product Data Sheet
Dicentrine hydrochloride
Catalog No. A58502
Dicentrine hydrochloride is an adrenergic receptor antagonist known for its anti-inflammatory and anti-cancer properties. It enhances TNF-α-induced apoptosis in A549 lung adenocarcinoma cells by increasing the activities of key apoptotic markers, including caspase-8, -9, -3, and poly(ADP-ribose) polymerase (PARP). Additionally, Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells by downregulating the TAK1, p38, JNK, and Akt signaling pathways, as well as reducing NF-κB and AP-1 transcriptional activities. This compound is valuable for research in cancer biology and therapeutic development.
Chemical Information
| Catalog Num | A58502 |
|---|---|
| M. Wt | 375.85 |
| Formula | C20H22ClNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 5742-03-0 |
| Synonyms | |
| SMILES | CN1[C@]2([H])C3=C(CC1)C=C(OCO4)C4=C3C5=CC(OC)=C(OC)C=C5C2.Cl |
Biological Activity
| Description | Dicentrine hydrochloride is an adrenergic receptor antagonist known for its anti-inflammatory and anti-cancer properties. It enhances TNF-α-induced apoptosis in A549 lung adenocarcinoma cells by increasing the activities of key apoptotic markers, including caspase-8, -9, -3, and poly(ADP-ribose) polymerase (PARP). Additionally, Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells by downregulating the TAK1, p38, JNK, and Akt signaling pathways, as well as reducing NF-κB and AP-1 transcriptional activities. This compound is valuable for research in cancer biology and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
