Product Data Sheet
NGD9002 free base
Catalog No. A58547
NGD9002 free base is a selective antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor, primarily targeting adrenergic receptors. It demonstrates significant inhibitory activity on CRF-induced colonic function stimulation, reducing fecal output responses with an IC50 value of 4.3 mg/kg. NGD9002 free base effectively blocks CRF-induced colonic secretory motility and mitigates acute water avoidance-induced defecation, while also preventing pain hypersensitivity reactions associated with repeated colonic distension. This compound is valuable for research into stress-related gastrointestinal disorders and the role of CRF in gut function.
Chemical Information
| Catalog Num | A58547 |
|---|---|
| M. Wt | 357.49 |
| Formula | C20H31N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 666256-06-0 |
| Synonyms | |
| SMILES | CC1=C(N=C(C(NC(CC)CC)=N1)OC)C2=CC=C(N=C2NC)C(C)C |
Biological Activity
| Description | NGD9002 free base is a selective antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor, primarily targeting adrenergic receptors. It demonstrates significant inhibitory activity on CRF-induced colonic function stimulation, reducing fecal output responses with an IC50 value of 4.3 mg/kg. NGD9002 free base effectively blocks CRF-induced colonic secretory motility and mitigates acute water avoidance-induced defecation, while also preventing pain hypersensitivity reactions associated with repeated colonic distension. This compound is valuable for research into stress-related gastrointestinal disorders and the role of CRF in gut function. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
