Product Data Sheet
Bethanidine sulfate
Catalog No. A58559
Bethanidine sulfate is a potent adrenergic receptor antagonist that functions primarily as an adrenergic neurone blocker. It inhibits the release of noradrenaline during nerve stimulation, resulting in sympathomimetic effects, particularly observed in animal models such as cats. This compound enhances smooth muscle responses to both adrenaline and noradrenaline and increases pressor responses to tyramine at lower doses. Additionally, while it briefly inhibits autonomic cholinergic mechanisms and can induce temporary neuromuscular paralysis at elevated doses, it does not lead to the depletion of pressor amine content in the iris, distinguishing it from other adrenergic blockers.
Chemical Information
| Catalog Num | A58559 |
|---|---|
| M. Wt | 275.32 |
| Formula | C10H17N3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 114-85-2 |
| Synonyms | BW 467C60 |
| SMILES | O=S(O)(O)=O.CN/C(NC)=N/CC1=CC=CC=C1.[0.5] |
Biological Activity
| Description | Bethanidine sulfate is a potent adrenergic receptor antagonist that functions primarily as an adrenergic neurone blocker. It inhibits the release of noradrenaline during nerve stimulation, resulting in sympathomimetic effects, particularly observed in animal models such as cats. This compound enhances smooth muscle responses to both adrenaline and noradrenaline and increases pressor responses to tyramine at lower doses. Additionally, while it briefly inhibits autonomic cholinergic mechanisms and can induce temporary neuromuscular paralysis at elevated doses, it does not lead to the depletion of pressor amine content in the iris, distinguishing it from other adrenergic blockers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
