Product Data Sheet
(-)-Domesticine
Catalog No. A58589
(-)-Domesticine is an anti-α-1D-adrenoceptor compound with demonstrated cytotoxic activity. It exhibits significant activity in MTS cytotoxicity assays against human colon cancer cell lines, specifically HCT-116 and Caco-2, with IC50 values ranging from 23 to 38 μM, comparable to the cytotoxic agent etoposide. This compound is also amenable to structural modifications, allowing the inclusion of alkoxy substituents and benzoate functional groups at the C1 position, which may enhance its biological activity in various cancer research applications.
Chemical Information
| Catalog Num | A58589 |
|---|---|
| M. Wt | 325.36 |
| Formula | C19H19NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 54325-07-4 |
| Synonyms | |
| SMILES | OC(C(OC)=C1)=C2C3=C1CCN(C)[C@]3([H])CC4=C2C=C5OCOC5=C4 |
Biological Activity
| Description | (-)-Domesticine is an anti-α-1D-adrenoceptor compound with demonstrated cytotoxic activity. It exhibits significant activity in MTS cytotoxicity assays against human colon cancer cell lines, specifically HCT-116 and Caco-2, with IC50 values ranging from 23 to 38 μM, comparable to the cytotoxic agent etoposide. This compound is also amenable to structural modifications, allowing the inclusion of alkoxy substituents and benzoate functional groups at the C1 position, which may enhance its biological activity in various cancer research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
