Product Data Sheet
A-123189
Catalog No. A58767
A-123189 is a selective and potent α1D antagonist, demonstrating inhibition constants (Kis) of 0.312 nM for human α1D and 0.17 nM for rat α1D. This compound exhibits a selectivity ratio of 10 to 20-fold for the α1D receptor when compared to human α1A and rat α1A receptors. A-123189 is useful for investigating the role of α1D adrenergic signaling in various biological processes and disease models.
Chemical Information
| Catalog Num | A58767 |
|---|---|
| M. Wt | 476.59 |
| Formula | C26H28N4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 255713-53-2 |
| Synonyms | |
| SMILES | O=C1N(C(C2=C(N1)SC=C2C3=CC=CC(C)=C3)=O)CCN4CCN(CC4)C5=CC=CC=C5OC |
Biological Activity
| Description | A-123189 is a selective and potent α1D antagonist, demonstrating inhibition constants (Kis) of 0.312 nM for human α1D and 0.17 nM for rat α1D. This compound exhibits a selectivity ratio of 10 to 20-fold for the α1D receptor when compared to human α1A and rat α1A receptors. A-123189 is useful for investigating the role of α1D adrenergic signaling in various biological processes and disease models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
