Product Data Sheet
L-748328
Catalog No. A58810
L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders.
Chemical Information
| Catalog Num | A58810 |
|---|---|
| M. Wt | 505.61 |
| Formula | C23H27N3O6S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 244192-93-6 |
| Synonyms | |
| SMILES | O=S(C1=CC=CC(OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(C3=CC=CC=C3)=O)O)=C1)(N)=O |
Biological Activity
| Description | L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
