Product Data Sheet
PD 168368
Catalog No. A59094
PD 168368 is a selective and potent neuromedin B receptor (NMB-R) antagonist, exhibiting a Ki value of 15–45 nM, and an IC50 of 96 nM for NMB-R. It also antagonizes the gastrin-releasing peptide receptor (GRPR) with an IC50 of 3500 nM. Furthermore, PD 168368 acts as a mixed agonist for FPR1, FPR2, and FPR3, demonstrating EC50 values of 0.57, 0.24, and 2.7 nM, respectively. This compound is valuable for studying NMB-R and GRPR-related signaling pathways and their implications in various biological processes and disease states.
Chemical Information
| Catalog Num | A59094 |
|---|---|
| M. Wt | 554.64 |
| Formula | C31H34N6O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 204066-82-0 |
| Synonyms | |
| SMILES | O=C([C@](C)(CC1=CNC2=C1C=CC=C2)NC(NC3=CC=C(C=C3)[N+]([O-])=O)=O)NCC4(CCCCC4)C5=NC=CC=C5 |
Biological Activity
| Description | PD 168368 is a selective and potent neuromedin B receptor (NMB-R) antagonist, exhibiting a Ki value of 15–45 nM, and an IC50 of 96 nM for NMB-R. It also antagonizes the gastrin-releasing peptide receptor (GRPR) with an IC50 of 3500 nM. Furthermore, PD 168368 acts as a mixed agonist for FPR1, FPR2, and FPR3, demonstrating EC50 values of 0.57, 0.24, and 2.7 nM, respectively. This compound is valuable for studying NMB-R and GRPR-related signaling pathways and their implications in various biological processes and disease states. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
