Product Data Sheet
AM281
Catalog No. A59183
AM281 is a selective antagonist of the cannabinoid receptor type 1 (CB1) with an IC50 value of 9.91 nM. This compound exhibits significant potency in inhibiting the CB1 receptor, while demonstrating a much lower affinity for the CB2 receptor with an IC50 of 13,000 nM. AM281 is primarily utilized in research applications related to endocannabinoid signaling, neurobiology, and the potential modulation of disorders involving CB1 receptor activity.
Chemical Information
| Catalog Num | A59183 |
|---|---|
| M. Wt | 557.21 |
| Formula | C21H19Cl2IN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 202463-68-1 |
| Synonyms | |
| SMILES | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(I)C=C3)=C1C)NN4CCOCC4 |
Biological Activity
| Description | AM281 is a selective antagonist of the cannabinoid receptor type 1 (CB1) with an IC50 value of 9.91 nM. This compound exhibits significant potency in inhibiting the CB1 receptor, while demonstrating a much lower affinity for the CB2 receptor with an IC50 of 13,000 nM. AM281 is primarily utilized in research applications related to endocannabinoid signaling, neurobiology, and the potential modulation of disorders involving CB1 receptor activity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
