Product Data Sheet
AM6545
Catalog No. A59184
AM6545 is a highly selective CB1 receptor antagonist that functions peripherally without crossing the blood-brain barrier (Ki=1.7 nM). By competitively inhibiting the CB1 receptors, AM6545 disrupts endocannabinoid signaling, thereby mitigating appetite stimulation and inflammatory responses without altering cAMP levels. This compound has been shown to significantly decrease food intake and body weight in murine models while improving metabolic syndrome-related renal impairment, including proteinuria, fibrosis, and insulin resistance. AM6545 is instrumental in research focused on obesity and its associated complications.
Chemical Information
| Catalog Num | A59184 |
|---|---|
| M. Wt | 556.46 |
| Formula | C26H23Cl2N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1245626-05-4 |
| Synonyms | |
| SMILES | CC1=C(C2=CC=C(C#CCCC#N)C=C2)N(C3=C(C=C(Cl)C=C3)Cl)N=C1C(NN4CCS(CC4)(=O)=O)=O |
Biological Activity
| Description | AM6545 is a highly selective CB1 receptor antagonist that functions peripherally without crossing the blood-brain barrier (Ki=1.7 nM). By competitively inhibiting the CB1 receptors, AM6545 disrupts endocannabinoid signaling, thereby mitigating appetite stimulation and inflammatory responses without altering cAMP levels. This compound has been shown to significantly decrease food intake and body weight in murine models while improving metabolic syndrome-related renal impairment, including proteinuria, fibrosis, and insulin resistance. AM6545 is instrumental in research focused on obesity and its associated complications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
