Product Data Sheet
CB1 antagonist 4
Catalog No. A59196
CB1 antagonist 4 is a selective inverse agonist for the cannabinoid receptor 1 (CB1), demonstrating an IC50 of 8.5 nM in human CB1 assays. This compound exhibits a notable selectivity for CB1 over CB2 receptors, with an IC50 of 604.9 nM. CB1 antagonist 4 effectively inhibits GTP binding in CB1-overexpressing cell membranes, with an EC50 of 18.5 nM, making it a valuable tool for studying CB1 receptor biology and signaling pathways.
Chemical Information
| Catalog Num | A59196 |
|---|---|
| M. Wt | 617.51 |
| Formula | C30H25Cl2F3N4OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1253641-65-4 |
| Synonyms | |
| SMILES | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CC)NN5CCCCC5 |
Biological Activity
| Description | CB1 antagonist 4 is a selective inverse agonist for the cannabinoid receptor 1 (CB1), demonstrating an IC50 of 8.5 nM in human CB1 assays. This compound exhibits a notable selectivity for CB1 over CB2 receptors, with an IC50 of 604.9 nM. CB1 antagonist 4 effectively inhibits GTP binding in CB1-overexpressing cell membranes, with an EC50 of 18.5 nM, making it a valuable tool for studying CB1 receptor biology and signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
