Product Data Sheet
URB447
Catalog No. A59216
URB447 is a peripherally restricted antagonist of the CB1 receptor, exhibiting an IC50 of 313 nM for rat CB1 and 41 nM for human CB2 receptors. This compound effectively reduces food intake and body weight gain in murine models by circumventing the central nervous system, thereby not interfering with central CB1-mediated responses. URB447 serves as a valuable tool for obesity research, providing insights into the peripheral modulation of cannabinoid signaling.
Chemical Information
| Catalog Num | A59216 |
|---|---|
| M. Wt | 400.90 |
| Formula | C25H21ClN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1132922-57-6 |
| Synonyms | |
| SMILES | O=C(C1=C(C)N(CC2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C1N)C4=CC=CC=C4 |
Biological Activity
| Description | URB447 is a peripherally restricted antagonist of the CB1 receptor, exhibiting an IC50 of 313 nM for rat CB1 and 41 nM for human CB2 receptors. This compound effectively reduces food intake and body weight gain in murine models by circumventing the central nervous system, thereby not interfering with central CB1-mediated responses. URB447 serves as a valuable tool for obesity research, providing insights into the peripheral modulation of cannabinoid signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
