Product Data Sheet
PGN36
Catalog No. A59221
PGN36 is a selective antagonist of the cannabinoid CB2 receptor (CB2R), with a Ki of 0.09 µM for CB2R and >40 µM for CB1R. This compound effectively inhibits the upregulation of collagen type I gene expression induced by promoters of bone metabolism. Notably, PGN36 is capable of crossing the blood-brain barrier, making it a valuable tool for studying frontotemporal dementia (FTD) and other neurological conditions.
Chemical Information
| Catalog Num | A59221 |
|---|---|
| M. Wt | 365.43 |
| Formula | C21H23N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1564253-75-3 |
| Synonyms | |
| SMILES | O=[N+](C1=CC2=C(N(CC3=CC=CC=C3)N=C2OCC4CCCCC4)C=C1)[O-] |
Biological Activity
| Description | PGN36 is a selective antagonist of the cannabinoid CB2 receptor (CB2R), with a Ki of 0.09 µM for CB2R and >40 µM for CB1R. This compound effectively inhibits the upregulation of collagen type I gene expression induced by promoters of bone metabolism. Notably, PGN36 is capable of crossing the blood-brain barrier, making it a valuable tool for studying frontotemporal dementia (FTD) and other neurological conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
