Product Data Sheet
A-836339
Catalog No. A59223
A-836339 is a selective agonist of the CB2 receptor, demonstrating Ki values of 0.4 nM and 0.8 nM for human and rat CB2 receptors, respectively. It exhibits significant analgesic, anti-inflammatory, gastric protective, and antioxidant activities. Activation of CB2 receptors in the dorsal root ganglia and spinal cord mediates its antinociceptive properties. Additionally, A-836339 reduces pro-inflammatory cytokines like TNF-α and IL-1β while enhancing the activity of antioxidant enzymes such as catalase and superoxide dismutase. This compound is valuable for research into inflammatory pain, neuropathic pain, gastric ulcers, and cerebral ischemia.
Chemical Information
| Catalog Num | A59223 |
|---|---|
| M. Wt | 310.45 |
| Formula | C16H26N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 959746-77-1 |
| Synonyms | |
| SMILES | CC1=C(C)S/C(N1CCOC)=N\C(C2C(C)(C)C2(C)C)=O |
Biological Activity
| Description | A-836339 is a selective agonist of the CB2 receptor, demonstrating Ki values of 0.4 nM and 0.8 nM for human and rat CB2 receptors, respectively. It exhibits significant analgesic, anti-inflammatory, gastric protective, and antioxidant activities. Activation of CB2 receptors in the dorsal root ganglia and spinal cord mediates its antinociceptive properties. Additionally, A-836339 reduces pro-inflammatory cytokines like TNF-α and IL-1β while enhancing the activity of antioxidant enzymes such as catalase and superoxide dismutase. This compound is valuable for research into inflammatory pain, neuropathic pain, gastric ulcers, and cerebral ischemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
