Product Data Sheet
MK-5596
Catalog No. A59320
MK-5596 is a selective and orally active inverse agonist of the cannabinoid receptor 1 (CB1R), exhibiting an IC50 of 1.0 nM and an EC50 of 5.8 nM. This compound demonstrates significant biological activity in promoting weight loss and appetite suppression. Additionally, MK-5596 exhibits mild inhibitory effects on several cytochrome P450 enzymes, including CYP3A4, CYP2C8, CYP2C9, and CYP2D6, with IC50 values ranging from 3.3 to 18 μM. This reagent is primarily utilized in research focused on obesity and its associated metabolic disorders.
Chemical Information
| Catalog Num | A59320 |
|---|---|
| M. Wt | 541.86 |
| Formula | C27H23Cl3N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1044586-68-6 |
| Synonyms | |
| SMILES | ClC1=CC=C(C2=CC3=C(OC(C)(C)C[C@H]3NC(C4=NNC(C)=C4)=O)N=C2C5=C(Cl)C=C(Cl)C=C5)C=C1 |
Biological Activity
| Description | MK-5596 is a selective and orally active inverse agonist of the cannabinoid receptor 1 (CB1R), exhibiting an IC50 of 1.0 nM and an EC50 of 5.8 nM. This compound demonstrates significant biological activity in promoting weight loss and appetite suppression. Additionally, MK-5596 exhibits mild inhibitory effects on several cytochrome P450 enzymes, including CYP3A4, CYP2C8, CYP2C9, and CYP2D6, with IC50 values ranging from 3.3 to 18 μM. This reagent is primarily utilized in research focused on obesity and its associated metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
