Product Data Sheet
GAT564
Catalog No. A59328
GAT564 is a potent allosteric modulator of the cannabinoid 1 receptor (CB1R), exhibiting EC50 values of 87 nM for cAMP and 320 nM for β-arrestin2. This compound enhances orthosteric ligand binding to hCB1R, indicating its role in modulating receptor activity. In research applications, GAT564 demonstrates significant efficacy as a topical agent, effectively reducing intraocular pressure (IOP) in ocular normotensive murine models of glaucoma.
Chemical Information
| Catalog Num | A59328 |
|---|---|
| M. Wt | 348.42 |
| Formula | C20H16N2O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2851895-01-5 |
| Synonyms | |
| SMILES | O=[N+](CC(C1=C(NC2=CC=CC=C21)C3=CSC=C3)C4=CC=CC=C4)[O-] |
Biological Activity
| Description | GAT564 is a potent allosteric modulator of the cannabinoid 1 receptor (CB1R), exhibiting EC50 values of 87 nM for cAMP and 320 nM for β-arrestin2. This compound enhances orthosteric ligand binding to hCB1R, indicating its role in modulating receptor activity. In research applications, GAT564 demonstrates significant efficacy as a topical agent, effectively reducing intraocular pressure (IOP) in ocular normotensive murine models of glaucoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
