Product Data Sheet
ABD459
Catalog No. A59363
ABD459 is a selective CB1 receptor antagonist that plays a crucial role in modulating food intake and sleep-wake cycles. It effectively displaces the CB1 agonist CP99540 with a Ki value of 8.6 nM and antagonizes CP55940-induced GTPγS binding, exhibiting a KB value of 7.7 nM. This compound may influence endogenous cannabinoid release via cholinergic activity and is relevant for research focused on neurological disorders and attentional processes.
Chemical Information
| Catalog Num | A59363 |
|---|---|
| M. Wt | 516.21 |
| Formula | C24H17BrCl2N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1047670-51-8 |
| Synonyms | |
| SMILES | O=C(C1=NN(C(C2=CC=C(Br)C=C2)=C1C)C3=CC=C(C=C3Cl)Cl)C4=CC=C(C=C4)OC |
Biological Activity
| Description | ABD459 is a selective CB1 receptor antagonist that plays a crucial role in modulating food intake and sleep-wake cycles. It effectively displaces the CB1 agonist CP99540 with a Ki value of 8.6 nM and antagonizes CP55940-induced GTPγS binding, exhibiting a KB value of 7.7 nM. This compound may influence endogenous cannabinoid release via cholinergic activity and is relevant for research focused on neurological disorders and attentional processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
