Product Data Sheet
L-736380
Catalog No. A59721
L-736380 is a potent antagonist of the cholecystokinin B (CCK-B) receptor, exhibiting a high affinity with an IC50 of 0.054 nM for CCK-B and 400 nM for CCK-A. This compound effectively inhibits gastric acid secretion in anesthetized rats with an ID50 of 0.064 mg/kg. Additionally, L-736380 demonstrates significant activity in ex vivo binding assays of [125I]CCK-8S in BKTO mouse brain membranes, with an ED50 of 1.7 mg/kg. Its function as a CCK-B antagonist makes it a valuable tool for studies related to gastrointestinal physiology and neuropharmacology.
Chemical Information
| Catalog Num | A59721 |
|---|---|
| M. Wt | 487.56 |
| Formula | C25H29N9O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 152885-49-9 |
| Synonyms | |
| SMILES | O=C(N[C@H]1C(N(C2=CC=CC=C2C(C3CCCCC3)=N1)C)=O)NC4=CC=CC(N(C5=NNN=N5)C)=C4 |
Biological Activity
| Description | L-736380 is a potent antagonist of the cholecystokinin B (CCK-B) receptor, exhibiting a high affinity with an IC50 of 0.054 nM for CCK-B and 400 nM for CCK-A. This compound effectively inhibits gastric acid secretion in anesthetized rats with an ID50 of 0.064 mg/kg. Additionally, L-736380 demonstrates significant activity in ex vivo binding assays of [125I]CCK-8S in BKTO mouse brain membranes, with an ED50 of 1.7 mg/kg. Its function as a CCK-B antagonist makes it a valuable tool for studies related to gastrointestinal physiology and neuropharmacology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
