Product Data Sheet
Astressin 2B
Catalog No. A59732
Astressin 2B is a selective antagonist of the corticotropin-releasing factor receptor 2 (CRFR2) with an IC50 of 0.57 nM. This compound disrupts the protective effects mediated by CRFR2, leading to increased intestinal damage in models of hemorrhagic injury and suggesting potential roles in studying inflammatory responses. Astressin 2B also reverses the protective effects of Urocortin 1 against intestinal complications and mitigates the anxiogenic effects of Urocortin 2, demonstrating its utility in research related to stress-induced anxiety and gastrointestinal pathology. This reagent is an effective tool for investigating CRFR2's role in intestinal protection and inflammatory processes.
Chemical Information
| Catalog Num | A59732 |
|---|---|
| M. Wt | 4041.69 |
| Formula | C183H307N49O53 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 681260-70-8 |
| Synonyms | |
| SMILES |
Biological Activity
| Description | Astressin 2B is a selective antagonist of the corticotropin-releasing factor receptor 2 (CRFR2) with an IC50 of 0.57 nM. This compound disrupts the protective effects mediated by CRFR2, leading to increased intestinal damage in models of hemorrhagic injury and suggesting potential roles in studying inflammatory responses. Astressin 2B also reverses the protective effects of Urocortin 1 against intestinal complications and mitigates the anxiogenic effects of Urocortin 2, demonstrating its utility in research related to stress-induced anxiety and gastrointestinal pathology. This reagent is an effective tool for investigating CRFR2's role in intestinal protection and inflammatory processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
