Product Data Sheet
BMS-665053
Catalog No. A59745
BMS-665053 is a potent corticotropin-releasing factor-1 (CRF1) receptor antagonist, exhibiting an IC50 of 1.0 nM. This compound effectively inhibits CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells, with an IC50 of 4.9 nM. BMS-665053 is valuable for research in neuroendocrine regulation and stress response pathways.
Chemical Information
| Catalog Num | A59745 |
|---|---|
| M. Wt | 424.66 |
| Formula | C16H14Cl3F2N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1173435-64-7 |
| Synonyms | |
| SMILES | ClC1=CN([C@H](C2CC2)C)C(C(NC3=C(Cl)C=C(OC(F)F)C=C3Cl)=N1)=O |
Biological Activity
| Description | BMS-665053 is a potent corticotropin-releasing factor-1 (CRF1) receptor antagonist, exhibiting an IC50 of 1.0 nM. This compound effectively inhibits CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells, with an IC50 of 4.9 nM. BMS-665053 is valuable for research in neuroendocrine regulation and stress response pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
