Product Data Sheet
NBI-34041
Catalog No. A59765
NBI-34041 is a selective, orally active nonpeptide antagonist of the CRF1 receptor, exhibiting an IC50 of 58.9 nM and a Ki of 4.0 nM for the human CRF1 receptor. This compound is characterized by its lack of inhibitory effects on the CRF2 receptor. NBI-34041 is utilized in research targeting depression and anxiety disorders, providing a valuable tool for investigating the role of CRF1 in stress-related conditions.
Chemical Information
| Catalog Num | A59765 |
|---|---|
| M. Wt | 417.37 |
| Formula | C22H26Cl2N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 268545-87-5 |
| Synonyms | SB-723620 |
| SMILES | CC1=NC2=C3C(N(C(CCC)CCC)CCN3N=C2C4=CC=C(Cl)C=C4Cl)=C1 |
Biological Activity
| Description | NBI-34041 is a selective, orally active nonpeptide antagonist of the CRF1 receptor, exhibiting an IC50 of 58.9 nM and a Ki of 4.0 nM for the human CRF1 receptor. This compound is characterized by its lack of inhibitory effects on the CRF2 receptor. NBI-34041 is utilized in research targeting depression and anxiety disorders, providing a valuable tool for investigating the role of CRF1 in stress-related conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
