Product Data Sheet
SN003
Catalog No. A59767
SN003 is a reversible antagonist of corticotropin-releasing factor receptor 1 (CRFR 1), exhibiting an IC50 of 241 nM and over 1000-fold selectivity for CRFR 1 compared to CRFR 2. This compound effectively suppresses corticotropin-releasing factor-induced adrenocorticotropic hormone (ACTH) release in vitro. Additionally, SN003 demonstrates the potential to mitigate depressive-like behavior in rat models, making it a valuable tool for research in neuropsychiatric disorders.
Chemical Information
| Catalog Num | A59767 |
|---|---|
| M. Wt | 355.43 |
| Formula | C19H25N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 197801-88-0 |
| Synonyms | |
| SMILES | CC1=CC(N(C(COC)CC)N=N2)=C2C(NC3=CC=C(OC)C=C3C)=N1 |
Biological Activity
| Description | SN003 is a reversible antagonist of corticotropin-releasing factor receptor 1 (CRFR 1), exhibiting an IC50 of 241 nM and over 1000-fold selectivity for CRFR 1 compared to CRFR 2. This compound effectively suppresses corticotropin-releasing factor-induced adrenocorticotropic hormone (ACTH) release in vitro. Additionally, SN003 demonstrates the potential to mitigate depressive-like behavior in rat models, making it a valuable tool for research in neuropsychiatric disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
