Product Data Sheet
ACT-777991
Catalog No. A59771
ACT-777991 is a selective antagonist of the CXCR3 receptor, demonstrating oral bioavailability. This compound effectively inhibits the migration of activated T cells in response to CXCL11, making it a useful tool for studying immune responses and inflammatory conditions. Its stability in microsomes and hepatocytes across various animal models further supports its potential applications in pharmacological research related to autoimmune diseases and cancer immunotherapy.
Chemical Information
| Catalog Num | A59771 |
|---|---|
| M. Wt | 550.48 |
| Formula | C20H20F6N8O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1967811-46-6 |
| Synonyms | |
| SMILES | OCC[C@@H](N(C(CN1C=NC(C)=N1)=O)CC2)CN2C(SC(C(F)(F)F)=N3)=C3C4=CN=C(C(F)(F)F)N=C4 |
Biological Activity
| Description | ACT-777991 is a selective antagonist of the CXCR3 receptor, demonstrating oral bioavailability. This compound effectively inhibits the migration of activated T cells in response to CXCL11, making it a useful tool for studying immune responses and inflammatory conditions. Its stability in microsomes and hepatocytes across various animal models further supports its potential applications in pharmacological research related to autoimmune diseases and cancer immunotherapy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
