Product Data Sheet
SX-517
Catalog No. A59774
SX-517 is a dual antagonist of CXCR2 and CXCR1, featuring a boronic acid structure. It effectively inhibits CXCL1-induced calcium flux with an IC50 of 38 nM and disrupts CXCL8-induced [(35)S]GTPγS binding, showing an IC50 of 60 nM, while also preventing ERK1/2 phosphorylation. This compound demonstrates significant anti-inflammatory properties in both humanized polymorphonuclear (PMN) cells and murine models, making it a valuable tool for research into inflammation-related pathways.
Chemical Information
| Catalog Num | A59774 |
|---|---|
| M. Wt | 382.22 |
| Formula | C19H16BFN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1240494-13-6 |
| Synonyms | |
| SMILES | OB(C1=CC=CC=C1CSC2=NC=C(C(NC3=CC=C(F)C=C3)=O)C=C2)O |
Biological Activity
| Description | SX-517 is a dual antagonist of CXCR2 and CXCR1, featuring a boronic acid structure. It effectively inhibits CXCL1-induced calcium flux with an IC50 of 38 nM and disrupts CXCL8-induced [(35)S]GTPγS binding, showing an IC50 of 60 nM, while also preventing ERK1/2 phosphorylation. This compound demonstrates significant anti-inflammatory properties in both humanized polymorphonuclear (PMN) cells and murine models, making it a valuable tool for research into inflammation-related pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
