Product Data Sheet
CXCR2-IN-2
Catalog No. A59777
CXCR2-IN-2 is a selective antagonist of the CXCR2 receptor, demonstrating high potency with an IC50 of 5.2 nM in a β-arrestin assay and 1 nM in the CXCR2 Tango assay. This compound exhibits significant selectivity, being approximately 730-fold more selective for CXCR2 over CXCR1 and greater than 1900-fold over other chemokine receptors. Additionally, CXCR2-IN-2 effectively inhibits Gro-α induced CD11b expression in human whole blood with an IC50 of 0.04 μM, making it a valuable tool for research into inflammatory processes and associated therapeutic applications.
Chemical Information
| Catalog Num | A59777 |
|---|---|
| M. Wt | 414.90 |
| Formula | C18H23ClN2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1838123-21-9 |
| Synonyms | |
| SMILES | O=C(N[C@H]1C(C)=CCC1)NC2=CC=C(Cl)C(S(=O)([C@]3(C)COCC3)=O)=C2O |
Biological Activity
| Description | CXCR2-IN-2 is a selective antagonist of the CXCR2 receptor, demonstrating high potency with an IC50 of 5.2 nM in a β-arrestin assay and 1 nM in the CXCR2 Tango assay. This compound exhibits significant selectivity, being approximately 730-fold more selective for CXCR2 over CXCR1 and greater than 1900-fold over other chemokine receptors. Additionally, CXCR2-IN-2 effectively inhibits Gro-α induced CD11b expression in human whole blood with an IC50 of 0.04 μM, making it a valuable tool for research into inflammatory processes and associated therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
