Product Data Sheet
SB-332235
Catalog No. A59783
SB-332235 is a potent, orally active nonpeptide antagonist of the chemokine receptor CXCR2, exhibiting an IC50 of 7.7 nM and demonstrating 285-fold selectivity for CXCR2 over CXCR1. This compound has been shown to effectively inhibit both acute and chronic models of arthritis in rabbits. Additionally, SB-332235 reduces the viability of acute myeloid leukemia (AML) cells, indicating its potential utility in cancer research and therapeutic applications for inflammatory diseases.
Chemical Information
| Catalog Num | A59783 |
|---|---|
| M. Wt | 410.66 |
| Formula | C13H10Cl3N3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 276702-15-9 |
| Synonyms | |
| SMILES | O=S(C1=C(Cl)C=CC(NC(NC2=CC=CC(Cl)=C2Cl)=O)=C1O)(N)=O |
Biological Activity
| Description | SB-332235 is a potent, orally active nonpeptide antagonist of the chemokine receptor CXCR2, exhibiting an IC50 of 7.7 nM and demonstrating 285-fold selectivity for CXCR2 over CXCR1. This compound has been shown to effectively inhibit both acute and chronic models of arthritis in rabbits. Additionally, SB-332235 reduces the viability of acute myeloid leukemia (AML) cells, indicating its potential utility in cancer research and therapeutic applications for inflammatory diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
