Product Data Sheet
(±)-NBI-74330 (racemic)
Catalog No. A59795
(±)-NBI-74330 is a potent and selective antagonist of the chemokine receptor CXCR3. This compound is effective in alleviating tactile and thermal hypersensitivity and demonstrates the ability to enhance the analgesic effects of morphine. In a rat neuropathic pain model, (±)-NBI-74330 reduces microglial cell activation, promotes astroglial cell activation, and downregulates specific CXCR3 ligands, making it a valuable tool for research in pain modulation and neuroinflammation.
Chemical Information
| Catalog Num | A59795 |
|---|---|
| M. Wt | 605.58 |
| Formula | C32H27F4N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 473722-68-8 |
| Synonyms | |
| SMILES | O=C1C2=C(N=C(C(C)N(CC3=CC=CN=C3)C(CC4=CC=C(C(C(F)(F)F)=C4)F)=O)N1C5=CC=C(C=C5)OCC)N=CC=C2 |
Biological Activity
| Description | (±)-NBI-74330 is a potent and selective antagonist of the chemokine receptor CXCR3. This compound is effective in alleviating tactile and thermal hypersensitivity and demonstrates the ability to enhance the analgesic effects of morphine. In a rat neuropathic pain model, (±)-NBI-74330 reduces microglial cell activation, promotes astroglial cell activation, and downregulates specific CXCR3 ligands, making it a valuable tool for research in pain modulation and neuroinflammation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
