Product Data Sheet
MLS1547
Catalog No. A59875
MLS1547 is a potent G protein-biased agonist of the dopamine D2 receptor (D2R) with a Ki value of 1.2 μM. It effectively stimulates G protein-mediated signaling pathways, exhibiting an EC50 of 0.37 μM in calcium mobilization assays. Additionally, MLS1547 functions as an antagonist for dopamine-stimulated β-arrestin recruitment to the D2R, demonstrating an IC50 of 9.9 μM. This compound is valuable for investigating D2R signaling mechanisms and exploring therapeutic strategies for disorders associated with dopamine dysregulation.
Chemical Information
| Catalog Num | A59875 |
|---|---|
| M. Wt | 354.83 |
| Formula | C19H19ClN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 315698-36-3 |
| Synonyms | |
| SMILES | OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3 |
Biological Activity
| Description | MLS1547 is a potent G protein-biased agonist of the dopamine D2 receptor (D2R) with a Ki value of 1.2 μM. It effectively stimulates G protein-mediated signaling pathways, exhibiting an EC50 of 0.37 μM in calcium mobilization assays. Additionally, MLS1547 functions as an antagonist for dopamine-stimulated β-arrestin recruitment to the D2R, demonstrating an IC50 of 9.9 μM. This compound is valuable for investigating D2R signaling mechanisms and exploring therapeutic strategies for disorders associated with dopamine dysregulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
